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The transient elevation of peripheral cytokines, such as IL-6 induces sustained effects through the following mechanisms: 1) Activated microglia can sustain a pro-inflammatory phenotype over extended periods, thereby potentially becoming a continuous source of IL-1 and TNF- within the central nervous system (127, 128)

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What the literature offers instead is a handful of fixed-duration administration schedules: 7 successive nights , placebo-controlled and double-blind, in 14 middle-aged chronic insomniacs

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